منابع مشابه
Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling.
Receptors for sex and adrenal steroid hormones are absent from fully sequenced invertebrate genomes and have not been recovered from other invertebrates. Here we report the isolation of an estrogen receptor ortholog from the mollusk Aplysia californica and the reconstruction, synthesis, and experimental characterization of functional domains of the ancestral protein from which all extant steroi...
متن کاملResurrecting an Ancient Enzyme to Address Gene Duplication
The molecular biological revolution of the past several decades has put into the hands of researchers a set of powerful tools for understanding life and its evolution. In this issue of PLOS Biology, Christopher Brown, Karin Voordeckers, Steven Maere, and Kevin Verstrepen put those tools to work to recreate long-vanished ancestral enzymes in vitro, testing their biochemical activity against exis...
متن کاملResurrecting ancestral genes in bacteria to interpret ancient biosignatures
Two datasets, the geologic record and the genetic content of extant organisms, provide complementary insights into the history of how key molecular components have shaped or driven global environmental and macroevolutionary trends. Changes in global physico-chemical modes over time are thought to be a consistent feature of this relationship between Earth and life, as life is thought to have bee...
متن کاملResurrecting the Dead (Molecules)
Biological molecules, like organisms themselves, are subject to genetic drift and may even become "extinct". Molecules that are no longer extant in living systems are of high interest for several reasons including insight into how existing life forms evolved and the possibility that they may have new and useful properties no longer available in currently functioning molecules. Predicting the se...
متن کاملThe Resurrecting Duckling - What Next?
In the context of the security of wireless ad hoc networks, we previously explored the problem of secure transient association between a master and a slave device in the absence of an online authentication server. We introduced the Resurrecting Duckling security policy model to address this problem. Master-slave relationships, however, do not exhaust the range of interesting interactions. We th...
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ژورنال
عنوان ژورنال: SSRN Electronic Journal
سال: 2020
ISSN: 1556-5068
DOI: 10.2139/ssrn.3528723